Uncontrolled elevated blood pressure can induce alterations in the blood-brain barrier, vascular remodeling and reduce regional cerebral blood flow which can lead to cognitive impairment.
Angiotensin receptor blockers (ARBs) are guideline-recommended antihypertensive medications that:
- Blocks angiotensin IItype 1 receptor (AT1R)
- Activates the peroxisome-proliferation-activated receptor gamma (PPARy)